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Transpl Infect Dis ; 22(5): e13306, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-176101

ABSTRACT

In late December 2019, China reported cases of respiratory illness in humans that involved a novel coronavirus SARS-CoV-2. On March 20, 2020, the first coronavirus disease 2019 (COVID-19) in Brazil was diagnosed, and by now, we present the report on the first case of COVID among transplant recipients in our country. A liver and kidney transplant patient with SARS-CoV-2 pneumonia without respiratory failure was treated in a clinical multimodal strategy consisting of symptomatic support therapy, immunosuppression reduction, use of anti-coronavirus drugs and heparin leading to a progressive improvement of patient symptoms till discharge. The authors also present a comprehensive review of published cases.


Subject(s)
COVID-19/diagnosis , Graft Rejection/prevention & control , Immunosuppressive Agents/adverse effects , Kidney Transplantation/adverse effects , SARS-CoV-2/immunology , Aged , Antiviral Agents/therapeutic use , Brazil , COVID-19/immunology , COVID-19/virology , COVID-19 Nucleic Acid Testing , Graft Rejection/immunology , Humans , Immunocompromised Host , Kidney Failure, Chronic/immunology , Kidney Failure, Chronic/surgery , Lung/diagnostic imaging , Male , RNA, Viral/isolation & purification , SARS-CoV-2/genetics , SARS-CoV-2/isolation & purification , Tomography, X-Ray Computed , Transplant Recipients , Treatment Outcome , COVID-19 Drug Treatment
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